What is your usual sleeping position? The best one is to lie on your back with your face up. Lying with your face down smooched into the pillow will result in more wrinkles and unwanted lines. It is difficult to control yourself in sleep, hence if you know that the only way for you to fall asleep is on your stomach, then at least try and keep your face off the edge of the pillow. This is how you will reduce squishing. To minimize the loss of collagen and prevent your skin from creasing, use a night cream containing hyaluronic acid.